Not signing your Win32 App detection scripts may sound as a very strange suggestion, and it's certainly not ideal from a security standpoint, but depending on how many applications you have that are using scripts for detection and/or requirement rules you may run into unexpected results…
Microsoft Intune Policy Limitations
When using Microsoft Intune for application deployments it's important to know that the platform was not designed to support a large set of applications, not only from a maximum size of each application perspective, but also from the sheer number of applications point of view.
Increasing the maximum size of each application can be easily addressed by placing a support case, but you still will have very real challenges of actually uploading and deploying applications larger than 8 GB. You can read more about that scenario here: Deploying Large Applications using Microsoft Intune.
If you use scripts as Win32 app detection and requirement rules/methods, you will quickly learn that signing those PowerShell scripts will lower the number of apps you can have in Intune. The reason is that signed scripts are larger in size, and Intune has a default maximum policy limit of 4 MB (total) in the JSON file that is sent down to the client.
Reaching the Policy Limit
When you hit the 4 MB policy limit you typically run into clients simply won't accept new applications anymore, or just being unhappy in general, which is even worse. Should you run into this, like when reaching the default size limit for applications, you have to reach out to Microsoft support and request a policy size increase.
Notes from the Lab
To test the limits in my lab tenant, I wrote a script that created a few hundred Win32 apps in Intune, all configured with both detection rules and requirement as PowerShell scripts. The two scripts combined was about 5 kb. The script also assigned all of these apps to a group that contained one of my test devices. Even after generating 600 applications, I was under the policy limit.
Resources
Here are some additional resources for verifying or troubleshooting Intune policy limits, as well as how you can verify how signing the scripts will impact your environment. After all it will depend on how many apps you have, whether you use requirement scripts, detections scripts, and the size of the signed scripts.
Note: As usual, verify this in a lab tenant first, not in your production tenant.
Patch My PC KB – Intune Policy Size Limit Considerations
https://patchmypc.com/intune-policy-limit-considerations
Deploy Code Signing Certificate with Intune – by Thomas Kurth
Deploy Code Signing Certificate with Intune – Workplace Ninja's (wpninjas.ch)